We are looking to recruit a Post-Doctorate Research Associate for a fixed term period of 2 years and full time with skills in cell biophysics to work on an exciting new Cancer Research UK funded project applying mechanobiology to study cell signalling.
The interdisciplinary project aims to study the mechanical activation of cell receptors, such as Notch, using novel technology developed in the Toseland lab. This approach is based around a fusion of magnetic tweezer based assays with high throughput-screening. You will work alongside an engineer/biophysicist to further develop this technology, and use this new technique, along with biochemical and cell imaging methods to monitor the receptor activity. We will aim to use this approach to perform drug screening assays under mechanically activated states.
To enhance the chances of success on this ambitious project, we encourage applicants with prior knowledge/experience of mammalian cell culture, cell imaging, cell signalling or force-based manipulation experiments (e.g. optical or magnetic tweezers).
As Post Doctoral Research Associate you will:
Develop an independent approach to the research project in both the design and execution of the necessary experiments.
Co-supervise with Dr. Chris Toseland and the postgraduate students working on the same project.
Take the lead in preparing manuscripts for publication describing the results of the work
Help supervise other lab members e.g. MSc/PhD students technically and academically
Attend national/international conferences relevant to the research and present research findings orally or as a poster.
Manage your own research and administrative activities, with guidance if required and report on progress regularly.
To be successful in this role you will have:
Training/experience with mammalian cell culture
PhD awarded (or about to be) in a relevant subject
Detailed experience of cell imaging (confocal/widefield)
Experience of molecular biology, Image analysis and processing and single molecule microscopy (SMLM)
The School of Biosciences is a part of the University’s Faculty of Science, and teaches undergraduate degree programmes in Biochemistry, Biology and Biomedical Sciences. Research projects are also undertaken in the same disciplines. The laboratory research interests of the School include:
o Protein Science
o Molecular Microbiology
o Biomolecular Medicine
o Genome Evolution
Start date for applications: 20th February 2018
Closing date for applications: 12th March 2018
Interviews are to be held: w/c 19th March 2018
Please see the links below to view the full job description and also to apply for this post. If you require further information regarding the application process please contact The Resourcing Team on jobs@kent.ac.uk quoting ref number: STM0885
Please note – applications must be made via the University’s online application system. You will be required to fill in the main details section of the application form as well as upload your CV and a cover letter. Your cover letter should clearly and explicitly address the requirements of the Person specification and you should provide clear evidence and examples in your application which back-up any assertions you make in relation to each criterion. We recommend a maximum of 4 x A4 sides for this document.
CVs or details sent directly to the department or via email cannot be considered.
——————–
Second position:
We are looking to recruit a Post-Doctorate Research Associate for a full time, fixed term period of 18 months, with skills in biophysics/engineering to work on an exciting new Cancer Research UK funded project to develop a new mechanobiology tool.
This is based around a fusion of magnetic tweezers with high-throughput screening. The PDRA will design and implement a system to apply a variable magnetic field across a microplate. The technology will be incorporated into imaging and microplate reader systems. The PDRA will work alongside a cell biophysicist to apply the technology to cell-based assays. We will aim to use this approach to perform drug screening assays under mechanically activated states.
To enhance the chances of success on this ambitious project, a research associate is required who has prior knowledge of designing/building magnetic tweezers, using electro-magnets or applying electromagnetic fields, and force-based manipulation experiments applied to biological systems.
As Post Doctoral research associate you will:
Develop an independent approach to the research project in both the design and execution of the necessary experiments.
Take the lead in preparing manuscripts for publication describing the results of the work
Use new techniques, methods and continually update knowledge and understanding of the field.
Help supervise other lab members e.g. MSc/PhD students technically and academically
Attend national/international conferences relevant to the research and present research findings orally or as a poster.
Manage your own research and administrative activities, with guidance if required and report on progress regularly.
To be successful in this role you will have:
Training/experience in working with Magnetic tweezers
PhD awarded (or about to be) in a relevant subject or equivalent
Detailed experience of designing/building magnetic tweezers
Training/experience with electromagnets/magnetic fields
To write up results for publication in scientific journals
The School of Biosciences is a part of the University’s Faculty of Science, and teaches undergraduate degree programmes in Biochemistry, Biology and Biomedical Sciences. Research projects are also undertaken in the same disciplines. The laboratory research interests of the School include:
o Protein Science
o Molecular Microbiology
o Biomolecular Medicine
o Genome Evolution
Start date for applications: 20th February 2018
Closing date for applications: 20th March 2018
Interviews are to be held: w/c 9th April 2018
Please see the links below to view the full job description and also to apply for this post. If you require further information regarding the application process please contact The Resourcing Team on jobs@kent.ac.uk quoting ref number: STM0886
Please note – applications must be made via the University’s online application system. You will be required to fill in the main details section of the application form as well as upload your CV and a cover letter. Your cover letter should clearly and explicitly address the requirements of the Person specification and you should provide clear evidence and examples in your application which back-up any assertions you make in relation to each criterion. We recommend a maximum of 4 x A4 sides for this document.
CVs or details sent directly to the department or via email cannot be considered.